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Research Scientist - Screening Specialist (m/w/d)

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Job Details

Job ID:
14250
Category:
Research Scientist
Location:
Germany
Job Type:
On-site

We are looking for a Research Scientist with deep expertise in peptide chemistry and chemical biology to help shape and deliver our mRNA display & DNA encoded libraries (DEL) services for external clients. You will work independently on peptide and small molecule discovery projects, refine and work on internal Research & Development. This is a hands-on, scientifically demanding role at the interface of chemistry, molecular biology and client delivery. You will work with a collaborative team of scientists, contribute to platform innovation, and work closely with external partners.

Requirements

  • Design, run and analyze mRNA display selections of cyclic peptide libraries against diverse targets
  • Maintain, optimize and extend the mRNA display platform, including library design, translation, cyclisation and selection workflows
  • Handle and quality-control nucleic acids (mRNA, DNA, cDNA), including library preparation, PCR/RT-PCR and next-generation sequencing readouts
  • Develop, validate and transfer assays for hit identification and confirmation
  • Contribute to project planning, timelines and documentation
  • Keep abreast of new developments in display technologies and cyclic peptide therapeutics, and propose improvements to our offering
  • Contribute to peptide and small-molecule DEL screening projects, including library screening, hit identification and data analysis

Qualifications

  • Master in chemistry, chemical biology, biochemistry or equivalent experience
  • Proven experience in mRNA display, including screening of cyclic peptide libraries and platform manipulation
  • Strong practical skills in nucleic acid handling (mRNA/DNA work, PCR, library construction, sequencing analysis)
  • Experience developing and optimizing assays for hit identification and validation
  • Excellent written and spoken English

Additional Skills

  • Experience in In Vitro peptide macrocyclization, bioconjugation & genetic code reprogramming
  • Biophysical assays for binding and affinity (e.g. SPR, BLI, ITC, FP)
  • Peptide characterization by LC-MS, HPLC and related analytical methods
  • Industry experience in a biotech, pharmaceutical or contract research / service environment, with an understanding of timelines, quality expectations and client delivery
  • Experience with DNA encoded libraries

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